MovDisordV3, Main, Exploration, bibRecord, 006122

Stiff‐person syndrome: An autoimmune disease

Identifieur interne : 006122 ( Main/Exploration ); précédent : 006121; suivant : 006123

Stiff‐person syndrome: An autoimmune disease

Auteurs : Philip Blum [États-Unis] ; Jankovic [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 1991.

RBID : ISTEX:46A51ABDA48DA09DE29E44CF9E7A34B0BD04394C

Descripteurs français

Pascal (Inist)
- Anticorps, Chimiothérapie, Corticostéroïde, Enzyme, Etude cas, Exploration, Exploration immunologique, Glutamate decarboxylase, Homme, Homme raide syndrome, Liquide céphalorachidien, Maladie autoimmune, Muscle strié pathologie, Système nerveux pathologie, Sérum, Traitement.
Wicri :
- topic : Enzyme, Homme.

English descriptors

KwdEn :
- Antibody, Autoantibodies (analysis), Autoimmune Diseases (diagnosis), Autoimmune Diseases (drug therapy), Autoimmune Diseases (immunology), Autoimmune disease, Autoimmune diseases, Baclofen (administration & dosage), Case study, Cerebrospinal fluid, Chemotherapy, Corticosteroid, Corticosteroid drugs, Diazepam (administration & dosage), Drug Administration Schedule, Drug Therapy, Combination, Enzyme, Exploration, Female, Glutamate Decarboxylase (immunology), Glutamate decarboxylase, Human, Humans, Immunological investigation, Male, Middle Aged, Muscle Rigidity (diagnosis), Muscle Rigidity (drug therapy), Muscle Rigidity (immunology), Muscle Tonus (drug effects), Nervous system diseases, Neurologic Examination, Prednisone (administration & dosage), Serum, Stiff man syndrome, Stiff‐person syndrome, Striated muscle disease, Treatment.
MESH :
- chemical , administration & dosage : Baclofen, Diazepam, Prednisone.
- chemical , analysis : Autoantibodies.
- diagnosis : Autoimmune Diseases, Muscle Rigidity.
- drug effects : Muscle Tonus.
- drug therapy : Autoimmune Diseases, Muscle Rigidity.
- immunology : Autoimmune Diseases, Glutamate Decarboxylase, Muscle Rigidity.
- Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Neurologic Examination.

Abstract

Stiff‐person syndrome (SPS) is characterized by progressive, usually symmetric rigidity of the axial muscles with superimposed painful spasms precipitated by tactile stimuli, passive stretch, volitional movement of affected or unaffected muscles, startling noises, and emotional stimuli. Electromyography demonstrates continuous normal motor unit potentials in the affected muscles. Both the rigidity and the spasms are relieved by sleep, general anesthesia, myoneural blockade, peripheral nerve blockade, and partially by diazepam. Evidence for an autoimmune etiology of SPS includes its association with other autoimmune diseases and autoantibodies and the presence of antibodies against glutamic acid decarboxylase (GAD) in the cerebrospinal fluid (CSF) of many affected patients. We describe two patients with this syndrome who had GAD antibodies in both CSF and serum. Partial relief of the symptoms in these patients by corticosteroid therapy provides additional evidence of an autoimmune etiology of SPS and of the role of immunotherapy in its treatment.

Url:

https://api.istex.fr/document/46A51ABDA48DA09DE29E44CF9E7A34B0BD04394C/fulltext/pdf

DOI: 10.1002/mds.870060104

Affiliations:

Le document en format XML

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<term>Autoantibodies (analysis)</term>
<term>Autoimmune Diseases (diagnosis)</term>
<term>Autoimmune Diseases (drug therapy)</term>
<term>Autoimmune Diseases (immunology)</term>
<term>Autoimmune disease</term>
<term>Autoimmune diseases</term>
<term>Baclofen (administration & dosage)</term>
<term>Case study</term>
<term>Cerebrospinal fluid</term>
<term>Chemotherapy</term>
<term>Corticosteroid</term>
<term>Corticosteroid drugs</term>
<term>Diazepam (administration & dosage)</term>
<term>Drug Administration Schedule</term>
<term>Drug Therapy, Combination</term>
<term>Enzyme</term>
<term>Exploration</term>
<term>Female</term>
<term>Glutamate Decarboxylase (immunology)</term>
<term>Glutamate decarboxylase</term>
<term>Human</term>
<term>Humans</term>
<term>Immunological investigation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Muscle Rigidity (diagnosis)</term>
<term>Muscle Rigidity (drug therapy)</term>
<term>Muscle Rigidity (immunology)</term>
<term>Muscle Tonus (drug effects)</term>
<term>Nervous system diseases</term>
<term>Neurologic Examination</term>
<term>Prednisone (administration & dosage)</term>
<term>Serum</term>
<term>Stiff man syndrome</term>
<term>Stiff‐person syndrome</term>
<term>Striated muscle disease</term>
<term>Treatment</term>
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<term>Muscle Rigidity</term>
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<term>Enzyme</term>
<term>Etude cas</term>
<term>Exploration</term>
<term>Exploration immunologique</term>
<term>Glutamate decarboxylase</term>
<term>Homme</term>
<term>Homme raide syndrome</term>
<term>Liquide céphalorachidien</term>
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<term>Muscle strié pathologie</term>
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<term>Sérum</term>
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<front><div type="abstract" xml:lang="en">Stiff‐person syndrome (SPS) is characterized by progressive, usually symmetric rigidity of the axial muscles with superimposed painful spasms precipitated by tactile stimuli, passive stretch, volitional movement of affected or unaffected muscles, startling noises, and emotional stimuli. Electromyography demonstrates continuous normal motor unit potentials in the affected muscles. Both the rigidity and the spasms are relieved by sleep, general anesthesia, myoneural blockade, peripheral nerve blockade, and partially by diazepam. Evidence for an autoimmune etiology of SPS includes its association with other autoimmune diseases and autoantibodies and the presence of antibodies against glutamic acid decarboxylase (GAD) in the cerebrospinal fluid (CSF) of many affected patients. We describe two patients with this syndrome who had GAD antibodies in both CSF and serum. Partial relief of the symptoms in these patients by corticosteroid therapy provides additional evidence of an autoimmune etiology of SPS and of the role of immunotherapy in its treatment.</div>
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Movement Disorders (revue)

Stiff‐person syndrome: An autoimmune disease

Stiff‐person syndrome: An autoimmune disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.